This paper examines the relationship between information and communication technologies (ICTs) and regional integration as a pathway to socio-economic development in Africa and South America. Both regions face a colonial legacy often characterized by stronger external economic and political ties to the developed world than between the countries in the region. The transfer of technology and building of infrastructure networks are also influenced by this North-South relationship. However, regional organizations are currently involved in efforts to strengthen technological infrastructure such as ICTs, as well as the enhancement of economic and political ties. This paper suggests a framework with which to combine research on integration, ICTs and development, and provides a brief analysis for each region of some ICT initiatives and their potential impact on regional integration. The paper concludes with suggested applications of this theoretical framework for further research, particularly in order to assess the desired outcome of development.